CO2 gas induced drug release from pH-sensitive liposome to circumvent doxorubicin resistant cells.
نویسندگان
چکیده
A novel pH-sensitive liposome encapsulating doxorubicin was prepared by a NH(4)HCO(3) gradient method. The liposomes were able to release the drug at pH 5.0 by the production of CO(2) gas. More importantly, the drug-loaded liposome effectively circumvented the breast cancer cells resistant to doxorubicin.
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ورودعنوان ژورنال:
- Chemical communications
دوره 48 40 شماره
صفحات -
تاریخ انتشار 2012